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PLC Clinic Resources

Clinical Perspectives

Evidence-based clinical insights from Dr. Papp and Dr. Myers

Reflections on Psychiatry & Psychology

Read our briefer posts in which we share some of our clinical perspectives.

Brief Clinical Posts

Deprescribing in Psychiatry: A Comprehensive Overview

Deprescribing pdf

A comprehensive overview of current clinical implications and history of deprescribing in psychiatry.

Ketamine Treatment in Psychiatric Practice: An Evidence-Based Clinical Overview

A clinical overview covering ketamine's mechanism of action, indications, treatment protocols, and safety considerations.

Ketamine Treatment pdf

Brain Zaps Part 1: Research Findings of Alexander Papp, MD

Brain Zaps Part 1 pdf

Brain Zaps: An Underappreciated Symptom of Antidepressant Discontinuation
by Papp A, Onton JA, 2018

Brain Zaps Part 2: Research Findings of Alexander Papp, MD

Brain Zaps Part 2 pdf

Triggers and Characteristics of Brain Zaps According to the Findings of an Internet Questionnaire
by Papp A, Onton JA, 2022

Scholarly Articles on Ketamine

Acute Antidepressant Effects Of Intramuscular Versus Intravenous Ketamine

Indian Journal of Psychological Medicine – 2014

The 'Ketamine And Me' Project - A qualitative study of patients’ experience of ketamine treatment for depression

Journal of Affective Disorders Reports – 2021

Cognitive Behavior Therapy May Sustain Antidepressant Effects of Intravenous Ketamine in Treatment-Resistant Depression

Psychotherapy and Psychosomatics – 2017

GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

Journal of Clinical Investigation - 2020

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder

JAMA Psychiatry – 2014

Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy

Journal of Psychoactive Drugs – 2019

Ketamine Treatment For Depression: Opportunities For Clinical Innovation And Ethical Foresight

The Lancet Psychiatry – 2017

Replication of Ketamine’s Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

Biological Psychiatry – 2012

Long-Term Maintenance With Intramuscular Ketamine for Treatment-Resistant Bipolar II Depression

American Journal of Psychiatry – 2012

Safety and efficacy of maintenance ketamine treatment in patients with treatment-refractory generalised anxiety and social anxiety disorders

Journal of Psychopharmacology – 2018

Side-effects Associated With Ketamine Use In Depression: A Systematic Review

The Lancet Psychiatry – 2018

Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine

Biological Psychiatry – 2012

What Is The Mechanism Of Ketamine’s Rapid-onset Antidepressant Effect? A Concise Overview Of The Surprisingly Large Number Of Possibilities

Journal of Clinical Pharmacy and Therapeutics – 2017

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