Brief Posts & Papers
By Alexander Papp, MD and Julie Myers, PsyD
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A clinical overview covering ketamine's mechanism of action, indications, treatment protocols, and safety considerations, with links to the supporting research.
And overview of the research findings on brain zaps from discontinuation of antidepressant medications.
Articles on Ketamine
Acute Antidepressant Effects Of Intramuscular Versus Intravenous Ketamine​​​​
​Indian Journal of Psychological Medicine – 2014
​Journal of Affective Disorders Reports – 2021
Psychotherapy and Psychosomatics – 2017
GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions
Journal of Clinical Investigations - 2020
Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder ​​​
JAMA Psychiatry – 2014
Journal of Psychoactive Drugs – 2019
Ketamine Treatment For Depression: Opportunities For Clinical Innovation And Ethical Foresight​
The Lancet Psychiatry – 2017
Biological Psychiatry – 2012
American Journal of Psychiatry – 2012
Journal of Psychopharmacology – 2018
Side-effects Associated With Ketamine Use In Depression: A Systematic Review​
The Lancet Psychiatry – 2018
Biological Psychiatry – 2012
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​Journal of Clinical Pharmacy and Therapeutics – 2017